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| Rank | Company Name | Market Capital | Headquarters Country |
| 1 | Eli Lilly | $509.89 B | United States |
| 2 | Novo Nordisk | $407.89 B | Denmark |
| 3 | Johnson & Johnson | $375.04 B | United States |
| 4 | AbbVie | $263.09 B | United States |
| 5 | Merck | $261.23 B | United States |
| 6 | Roche | $221.17 B | Switzerland |
| 7 | Novartis | $212.19 B | Switzerland |
| 8 | Astrazeneca | $209.91 B | United Kingdom |
| 9 | Pfizer | $187.27 B | United States |
| 10 | Amgen | $145.75 B | United States |
| 11 | Sanofi | $134.48 B | France |
| 12 | Bristol-Myers Squibb | $121.25 B | United States |
| 13 | Gilead Sciences | $93.37 B | United States |
| 14 | Vertex Pharmaceuticals | $89.74 B | United States |
| 15 | CVS Health | $89.67 B | United States |
| 16 | Regeneron Pharmaceuticals | $89.33 B | United States |
| 17 | Zoetis | $80.08 B | United States |
| 18 | CSL | $76.76 B | Australia |
| 19 | GlaxoSmithKline | $74.23 B | United Kingdom |
| 20 | Merck KGaA | $72.82 B | Germany |
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(updated on 2-Oct-2023)