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| Rank | Company Name | Market Capital | Headquarters Country |
| 1 | Johnson & Johnson | $401.97 B | United States |
| 2 | Novo Nordisk | $321.90 B | Denmark |
| 3 | Eli Lilly | $313.76 B | United States |
| 4 | Merck | $273.22 B | United States |
| 5 | AbbVie | $272.59 B | United States |
| 6 | Roche | $230.82 B | Switzerland |
| 7 | Pfizer | $226.33 B | United States |
| 8 | Astrazeneca | $200.17 B | United Kingdom |
| 9 | Novartis | $174.01 B | Switzerland |
| 10 | Bristol-Myers Squibb | $141.62 B | United States |
| 11 | Amgen | $125.43 B | United States |
| 12 | Sanofi | $119.16 B | France |
| 13 | Gilead Sciences | $99.44 B | United States |
| 14 | CVS Health | $96.82 B | United States |
| 15 | CSL | $96.73 B | Australia |
| 16 | Regeneron Pharmaceuticals | $83.12 B | United States |
| 17 | Merck KGaA | $78.31 B | Germany |
| 18 | Zoetis | $75.79 B | United States |
| 19 | Vertex Pharmaceuticals | $75.65 B | United States |
| 20 | GlaxoSmithKline | $68.75 B | United Kingdom |
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